ROLE OF SERUM INTERLEUKIN – 10 AND INTERLEUKIN -28B GENE POLYMORPHISMS IN PREDICTING TREATMENT RESPONSE OF HEPATITIS C PATIENTS
نویسندگان
چکیده
منابع مشابه
the role of interleukin-28b gene polymorphisms in chinese patients with chronic hepatitis c treated with pegylated interferon and ribavirin
patients and methods il28b rs8099917 was genotyped in 263 patients with hepatitis c virus (hcv) infection and 244 healthy controls in tianjin, china using taqman snp genotyping method. the roles of rs8099917 and clinical characteristics in antiviral treatment were analyzed by logistic regression. results among 263 patients with chronic hcv infection, 223 had a tt genotype (84.8%). frequencies o...
متن کاملRole of Interleukin-28B Genetic Polymorphisms in Korean Patients with Hepatitis C Virus Infection
BACKGROUND/AIMS This study investigated the role of single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B) gene with respect to clinical outcomes and the antiviral response in hepatitis C virus (HCV) infection to suggest the practical utility of IL28B genotyping in Korea. METHODS Two SNPs near IL28B, rs12979860 and rs8099917, were analyzed using an allelic discrimination assa...
متن کاملThe Role of Interleukin-28b Gene Polymorphisms in Chinese Patients With Chronic Hepatitis C Treated With Pegylated Interferon and Ribavirin
BACKGROUND Interleukin-28B (IL28B) single nucleotide polymorphism (SNP) rs8099917 has been described to be associated with response to treatment with pegylated interferon and ribavirin (PEG-IFN/RBV) in patients with chronic hepatitis C from the North America, Europe, Asia countries like Japan and Taiwan. Whether this holds true for Chinese patients remains unknown. OBJECTIVES We aimed to stud...
متن کاملThe frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis
ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The a...
متن کاملStudy of Interleukin 28B rs12979860 and rs8099917 Polymorphisms and T-helper 1 Response in Hepatitis C Virus Patients.
HCV infection is a serious public health problem and a leading cause of chronic liver disease. It affects nearly 3% of the world's population with an associated high mortality. Egypt has the highest prevalence of HCV infection in the world (estimated at >10%). Peg-IFN-α and RBV are the most widely used therapy for HCV. Unfortunately, the rate of SVR is around 50%. In addition, it is expensive a...
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ژورنال
عنوان ژورنال: Zagazig University Medical Journal
سال: 2017
ISSN: 2357-0717
DOI: 10.21608/zumj.2017.4582